Functional Excipients for the Formulation of Solid Oral Dosage Forms
Fully Formulated Conventional and Modified Release Film Coating Systems
Information on a Variety of Applications to Enhance Food Products
Pharmaceutical Printing Inks
Alphabetical Listing of All Products
Products by Excipient Functionality
Formulation Information for Specific Applications
Technical Information for Solid Oral Dosage Manufacturing Processes
Useful Tools for the Pharmaceutical Formulator
Technical Formulation and Development Seminars and Forums
On-tablet Authentication and Brand Protection
Brand Enhancement Services for Tablets
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Useful Tools to Assist Pharmaceutical Product Development
Extensive Collection of Articles, Product Literature, Application Data and Regulatory Documents
Applications
Assessment of Low-Dose Content Uniformity of IndomethacinThis ADS was adapted from an academic poster comparing three excipients and their role in achieving content uniformity in a formula containing a very low dose of indomethacin.
Use of Starch 1500® to Improve the Uniformity of a Low Dose Direct Compression Chlorpheniramine FormulationThis study examines the effect of Starch 1500 as an agent for pre-blending a low dose active to ensure good uniformity in a direct compression chlorpheniramine maleate (4mg) formulation.
Formulation of Low Dose Medicines - Theory and PracticeAn article written by Hashim Ahmed, Ph.D. and Navnit Shah, Ph.D. of Hoffmann-LaRoche Inc. evaluating multiple excipients for content uniformity in a low dose application.
Investigation of Ethylcellulose in the Preparation of Theophylline Extended Release Inert Matrix TabletsThis research illustrates the influence of EC particle size and molecular weight on drug release from inert matrices containing a sparingly water soluble drug. The influence of varying the polymer concentration, filler choice and compression force on drug release was also evaluated.
Investigation of Moisture-Activated Granulation of Hydrophilic Polymer Blends in Verapamil HCl Extended Release MatricesADS adapted from 2009 CRS poster, Investigation of Moisture-Activated Granulation of Hydrophilic Polymer Blends in Verapamil HCl Extended Release Matrices
Investigation of the Effect of Tablet Geometry and Film Coating on Drug Release from Hypromellose Matrices at Constant Surface Area to Volume Ratio Using Two Model DrugsADS adapted from 2009 CRS poster, Investigation of the Effect of Tablet Geometry and Film Coating on Drug Release from Hypromellose Matrices at Constant Surface Area to Volume Ratio Using Two Model Drugs
The Influence of Hydro-Alcoholic Media on Hypromellose Matrix SystemsThis poster reprint investigates the effect of hydro-alcoholic dissolution media on the swelling and drug release properties of METHOCEL™ matrices.
The Influence of In-vitro Dissolution Method on the Release of a Highly Water Soluble Drug from Polyethylene Oxide and Hypromellose Hydrophilic Extended Release MatricesThe objective of this study was to investigate the influence of different dissolution methods on the release of a high solubility drug from an ER matrix formulation containing either HPMC or PEO as the rate-controlling polymer.
Investigation of Aqueous Ethylcellulose Dispersion in Extended Release Metformin Inert Matrices ADS adapted from 2009 CRS poster, Investigation of Aqueous Ethylcellulose Dispersion in Extended Release Metformin Inert Matrices
The Influence of In Vitro Dissolution Method on Lansoprazole Release from Enteric Coated Mini-TabsADS adapted from 2009 CRS poster, The Influence of In Vitro Dissolution Method on Lansoprazole Release from Enteric Coated Mini-Tabs
Effectiveness of Moisture Barrier Coatings on Various Tablet CoresEvaluation of Opadry® amb compared with alternative coating formulations and their effect on moisture uptake.
Opadry® amb - Moisture Vapor TransmissionEvaluation of Opadry amb compared with alternative coating formulations and their effect on moisture uptake.
Direct Compression Formula using Starch 1500® with Ranitidine HCL (150mg) Tablets, Film Coated with Opadry® II (85 Series)Data demonstrating the ability of a formulator challenged with a moisture sensitive active to produce a robust dosage with excellent physical and chemical stability utilizing Starch 1500 in the core and Opadry II as the film coat.
Free and Bound Water in Starch 1500® compared to other commonly used excipientsComparison of Water Activity v LOD of commonly used excipients.
The Effect of Starch 1500® on the Stability of Aspirin Tablets Stored Under Accelerated ConditionsPresents data to suggest that Starch 1500 may be inhibiting water activity within the formulation and retarding moisture interaction with the aspirin.
Formulation of Acetylsalicylic Acid Tablets for Aqueous Enteric Film CoatingThe goal of this study was to determine which combination of excipients would result in an Aspirin tablet core that would be suitable for use in an aqueous enteric film-coating process.
Application of Powder Layering Technology and Aqueous Enteric CoatingThis ADS was adapted from the AAPS 2006 poster demonstrating the successful use of Acryl-EZE® 93F19255, when applied onto dry powder layered lansoprazole multiparticulates.
Evaluation of the Enteric Performance of Lansoprazole Mini-Tabs Coated in a Perforated PanThe focus of this study was to investigate the potential of successful manufacture and enteric coating of lansoprazole mini-tabs using methacrylic acid co-polymers in a perforated pan. Along with other findings, this study will show that the mechanical strength of the mini-tabs significantly improved upon application of a seal-coat.
The Influence of Molecular Weight on Drug Release from Ethylcellulose Barrier Membrane MultiparticulatesADS adapted from 2009 CRS poster, The Influence of Molecular Weight on Drug Release from Ethylcellulose Barrier Membrane Multiparticulates
The Influence of Solvent Type on Extended Release Coating with Ethylcellulose Barrier MembranesThe objective of this work was to investigate the influence of four acceptable solvent combinations on EC solution viscosity and consequent drug release from coated beads.
The Influence of Plasticizer Type and Level on Drug Release from Ethylcellulose Barrier Membrane MultiparticulatesADS adapted from 2009 CRS poster, The Influence of Plasticizer Type and Level on Drug Release from Ethylcellulose Barrier Membrane Multiparticulates
The Influence of Coating System Type on Acetaminophen Release from Ethylcellulose Barrier Membrane Coated MultiparticulatesADS adapted from 2009 CRS poster,The Influence of Coating System Type on Acetaminophen Release from Ethylcellulose Barrier Membrane Coated Multiparticulates
Application of an Aqueous Ethylcellulose Dispersion in Multiple-Unit Pellet Systems.The objective of this poster reprint was to investigate drug release from compressed multiple-unit pellet systems, coated with an aqueous ethylcellulose dispersion (Surelease® E-7-19040).
Comparative Study of Theoretical Versus Actual Weight Gain for a Surelease® Barrier Membrane on Coated PelletsThis poster reprint outlines an analytical method to determine the quantity of ethylcellulose applied during coating, on multiparticulates.
Effect of Hypromellose as a Pore-Former in Aqueous Ethylcellulose Dispersion: Characterization of Dispersion PropertiesThis poster reprint investigates the effect of HPMC as a pore-former on: stability of aqueous EC dispersion (Surelease®); quality of the free films prepared from these mixtures, and interactions between the HPMC and EC dispersion.
Identification and Influence of Critical Coating Process Parameters on Drug Release from a Fully Formulated Aqueous Ethylcellulose DispersionThe objective of this poster reprint was to identify and study the influence of critical film coating process parameters for Surelease® aqueous ethylcellulose dispersion, on drug release behavior and the output or response variables of that process.
Investigation of the Relationship between Formulation Variables and Drug Release in Aqueous Ethylcellulose CoatingThis poster reprint summarizes the effect of pore former on the drug release of various actives from drug layered beads coated with Surelease®, aqueous ethylcellulose dispersion.
Predictability of Drug Release from Multiparticulate Systems Coated with an Aqueous Ethylcellulose DispersionThis poster reprint examines drug release from drug layered beads varying in substrate size, and Surelease® coating level.
The Effect of Hypromellose as a Pore-Former on Drug Release from Aqueous Ethylcellulose Film-Coated Dipyridamole-Loaded Non-Pareil BeadsThis poster reprint investigates the influence of pore-formers on the release of a poorly water-soluble drug, dipyridamole, from non-pareil beads coated with an aqueous ethylcellulose dispersion (Surelease® NG E-7-19050).
The Influence of Post Coating Thermal Treatment on Film Properties and Drug Release from Ethylcellulose Barrier Membrane Coating SystemsThe results of this study demonstrate that post coating treatment can affect both physico-mechanical properties of EC films and drug release from EC-coated multi-particulates.
Application of Acryl-EZE® 93F on Rabeprazole Sodium Tablets (20 mg) This ADS was adapted from the 2006 AAPS poster demonstrating the successful use of Acryl-EZE 93F19255, when applied onto rabeprazole sodium tablets.
Aqueous Enteric Coating Application on Non-Banded Hard Gelatin Capsules This ADS was adapted from the 2006 AAPS poster that investigates the delayed release performance of Acryl-EZE® 93F19255, when applied onto omeprazole filled, hard gelatin capsules.
Controlled Permeability Films for Programmable Drug ReleaseThis ADS was adapated from the 2006 CRS poster investigating the influence of sodium alginate or hypromellose (HPMC) as pore formers in a delayed release film coating to achieve modified enteric drug release.
Enteric Coating of Tablets with Debossed LogosThis ADS was adapated from the 2004 CRS poster demonstrating how to successfully enteric coat tablets which contain a debossed logo.
New Coating Process for the Application of Enteric Coatings to Small Tablet SamplesThis ADS was adapted from the 2005 AAPS poster investigating the rapid application of an aqueous enteric coating system onto very small batch sizes of tablets using a novel coating process technology, the SUPERCELL™ process from Niro.
Preparation of Robust, Enteric-Coated Dosage Forms Utilizing Acryl-EZE®This ADS was adapted from the 2002 AAPS poster providing solutions for the application of aluminum lake pigmented Acryl-EZE formulations onto various actives, to provide stable, reproducible drug release.
Preparation of Stable, Gastro-Resistant Diclofenac Sodium Tablets, Utilizing Optimized Film-Coating Combinations with Acryl-EZE®This ADS was adapted from the 2003 CRS poster demonstrating how to reduce your overall coating process time and achieve drug product stability, by incorporating pigments directly into the Acryl-EZE enteric film layer.
Production-Scale Process and Performance Comparison of Two Fully-Formulated Aqueous Enteric Coating SystemsThis ADS was adapted from the 2001 AAPS poster summarizing the production scale evaluation of Acryl-EZE® and Sureteric® for coating process, enteric protection, and finished product stability.
The Effect of Superdisintegrant on Acid Resistance of Enteric Coated TabletsThis ADS was adapted from the 2005 AAPS poster investigating the influence of superdisintegrant type and level on the performance of two enteric coated tablet formulations.
The Influence of Gastric Media (In-Vitro) on the Performance of Delayed Release Proton Pump Inhibitor Dosage FormsThis ADS was adapated from the 2005 AAPS poster investigating the enteric performance of aqueous enteric-coated tablet formulations containing proton pump inhibitors (PPI’s) in bio-relevant media, which better simulates the gastric environment of a patient on a multiple dose regimen of PPI’s.
Modulation of Drug Release from Hydrophilic MatricesThis article examines the concept of synergies between hypromellose and other polymers to modulate the drug release rate from matrix dosage forms.
Drug Release From Acrylic Based Opadry® Enteric (94 Series) Coated TabletsOpadry® Enteric (94 series), enteric coating system, is a fully formulated, delayed release coating system for solid oral dosage forms, based on MAC, specifically the poly [methacrylic acid, methyl methacrylate (1:1), type A].
Opadry® Enteric 91, 94, 95 seriesOpadry Enteric is a family of fully formulated, delayed release coating systems for solid oral dosage forms, which are applied by organic or hydro-alcoholic processing techniques.
Hypromellose as a Pore Former in Aqueous Ethylcellulose Dispersion: Stability and Film PropertiesThis poster reprint investigates the effect of HPMC as a pore-former on: stability of aqueous EC dispersion (Surelease®); quality of the free films prepared from these mixtures, and interactions between the HPMC and EC dispersion.
Opadry® tm - Taste Mask ComparisonProduct technology summary including stability profile, film properties, color effects and regulatory guidelines.
Taste Masking Performance and Stability of Opadry® tmTaste and dissolution profile studies of Bitrex and Caffeine tablet cores coated with Opadry tm.
