Effect of Processing Conditions on Hypromellose Matrix Formulations of Acetaminophen Prepared by a High Shear Wet Granulation Process
This ADS was adapted from the CRS 2010 poster providing processing guidelines for developing a hypromellose matrix formulation using a wet granulation process; with the extra-granular addition of HPMC and Starch 1500 resulting in increased tablet hardness.

Fluid Bed Method for Increasing the Compactability of Echinacea Purpurea Powder using Starch 1500® and fumed silica
Treating a high dose, poorly compressible herbal powder with Starch 1500 and fumed silica to increase the compressibility of the powder.

High Shear Granulation with Starch 1500®, Partially Pregelatinized Maize Starch - Evaluation of Process Parameters by Design of Experiments (DOE)
ADS adapted from 2007 AAPS poster evaluating the impact of process variables and formulation on the granulation and tablet properties of formulations, utilizing Starch 1500®, partially pregelatinized maize starch, as a binder and disintegrant through Design of Experiments (DOE).

Investigation of a Venlafaxine HCl (37.5mg) Extended Release Formulation using Hypromellose (HPMC) Matrices
This ADS was adapted from the 2006 CRS poster which provides a method to minimize a burst of drug release typically observed in the early phases of release of highly soluble actives from METHOCEL™ matrices. Granulation of the drug, and coating on top of the matrix, with Surelease, were investigated.

Starch 1500®, Partially Pregelatinized Maize Starch, Used as a Binder Disintegrant in High Shear Wet Granulation Comparison to Povidone and Croscarmellose Sodium
This study compares the high shear granulation and tablet properties of two formulations. One is based on a polymer granulation binder, PVP, in combination with a super disintegrant, croscarmellose sodium (CCS). This formulation was developed external to Colorcon. The other formulation utilized partially pregelatinized maize starch, Starch 1500, as both the binder and the disintegrant.

The Relevance of USP Methodology in the Development of a Verapamil Hydrochloride (240mg) Extended Release Formulation
This ADS was adapted from the 2005 CRS poster examining the impact of the type of dissolution testing method on drug release from extended release verapamil hydrochloride METHOCEL™ matrices.

Wet Granulation of Acetaminophen with Starch 1500®
Highlights the performance improvements in tablet hardness and disintegration of Starch 1500 over PVP.

Fluid Bed Granulation of Acetaminophen: Effect of Key Process Variables on Granule and Tablet Characteristics
Illustrates the use of Design of Experiment (DOE) as a tool to access the effect of potential process parameter changes on product quality and overall process operation.