Direct Compression Metformin HCl 500mg Extended Release Formula Based on Hypromellose
This ADS was adapted from the 2005 CRS poster investigating the formulation of an extended release, direct compression Metformin HCl (500 mg) matrix tablet using METHOCEL™.

Investigation of a Venlafaxine HCl (37.5mg) Extended Release Formulation using Hypromellose (HPMC) Matrices
This ADS was adapted from the 2006 CRS poster which provides a method to minimize a burst of drug release typically observed in the early phases of release of highly soluble actives from METHOCEL™ matrices. Granulation of the drug, and coating on top of the matrix, with Surelease, were investigated.

Maintaining Similar Drug Release from Hypromellose Matrices with Identical Dimensions but Different Dose Strengths
This ADS provides a method to maintain similar drug release, tablet shape and weight, from a METHOCEL™ matrix, while adjusting the drug dose.

Mathematical Model for Simulation and Control of Drug Release from Hydrophilic Matrices
This ADS was adapted from the 2007 CRS poster which utilizes mathematical modeling to summarize the influence of several formulation variables on drug release from METHOCEL™ matrices.

Modulation of Drug Release from Hypromellose (HPMC) Matrices: Suppression of the Initial Burst Effect
This ADS was adapted from the 2006 AAPS poster which provides a method to minimize a burst of drug release typically observed in the early phases of release of highly soluble actives from METHOCEL™ matrices.

The Effect of Film Coating and Storage Conditions on the Performance of Metformin HCl 500 mg Extended Release Hypromellose Matrices
This ADS was adapted from the 2006 CRS poster investigating the influence of three film coating systems on the performance of Metformin HCl (500mg) extended release (ER) Hypromellose matrices stored under different conditions up to 12 months.

The Effect of In Vitro Dissolution Parameters on the Release Rate of a Low Dose, Low Solubility Drug from Extended Release Hypromellose Matrix Formulations
This ADS was adapted from the 2006 CRS poster examining the impact of dissolution testing parameters on a low dose, low solubility, METHOCEL™ matrix formulation, compared to a marketed reference product.

The Influence of Anionic Polymers on Hydrochlorothiazide Extended Release Hypromellose Matrices
This ADS was adapted from the 2007 AAPS poster summarizing the effect of blending anionic polymers (carbomer and polyvinyl acetate phthalate [PVAP, Phthalavin®]) with HPMC, on extending the release of a very slightly soluble drug (~1.0 mg/ml). The effects of varying the polymer blend ratio and excipient choice were studied in terms of drug release profile and textural properties of the hydrated matrix tablets.

The Influence of Formulation Variables on Drug Release Kinetics from Hypromellose Extended Release Matrices
This ADS was adapted from the 2006 CRS poster which utilizes mathematical modeling to summarize the influence of several formulation variables on drug release from METHOCEL™ matrices.

The Influence of Hydrodynamic Conditions on Verapamil Hydrochloride Release from Hydrophilic Matrices Using Ionic and Non-Ionic Polyers
This ADS was adapted from the 2008 AAPS poster. The purpose of this study was to investigate the effects of hydrodynamic conditions on drug release rates from a matrix tablet with a soluble active ingredient, using different combinations of HPMC. The study will show that the combination of HPMC with ionic polymers in ER matrices provides robust formulations which are insensitive to hydrodynamic conditions.

The Influence of In Vitro Dissolution Method on the Release of a Highly Water Soluble Drug from Polyethylene Oxide and Hypromellose Hydrophilic Extended Release Matrices
This ADS was adapted from the 2008 AAPS poster. The objective of this study was to investigate the influence of different dissolution methods on the release of a high solubility drug from an ER matrix formulation containing either HPMC or PEO as the rate-controlling polymer.

The Relevance of USP Methodology in the Development of a Verapamil Hydrochloride (240mg) Extended Release Formulation
This ADS was adapted from the 2005 CRS poster examining the impact of the type of dissolution testing method on drug release from extended release verapamil hydrochloride METHOCEL™ matrices.

Use of Roller Compaction in the Preparation of Verapamil Hydrochloride Extended Release Matrix Tablets Containing Hydrophilic Polymers
This ADS was adapted from the 2008 CRS poster evaluating the effects of roller compaction on the flow and compressibility of blends of HPMC, polyvinyl acetate phthalate(PVAP) and carbomer [cross-linked poly (acrylicacid)]. Drug release of an ER verapamil HCl matrix formulation containing this blend was also evaluated.

METHOCEL™ DC Product Information Brochure
Product features and benefits.

Application of Ethylcellulose in Preparation of Extended Release Theophylline Inert Matrix Tablets by Wet Granulation
The outcome of this study illustrates that an aqueous ethylcellulose dispersion (Surelease™) was successfully utilized to formulate and manufacture extended release theophyllin inert matrices. The influence of varying polymer concentration, filler choice and compression force on drug release profiles were studied as well.

Comparative Study of Theoretical Versus Actual Weight Gain for a Surelease® Barrier Membrane on Coated Pellets
This poster reprint outlines an analytical method to determine the quantity of ethylcellulose applied during coating, on multiparticulates.

Effect of Hypromellose as a Pore-Former in Aqueous Ethylcellulose Dispersion: Characterization of Dispersion Properties
This poster reprint investigates the effect of HPMC as a pore-former on: stability of aqueous EC dispersion (Surelease®); quality of the free films prepared from these mixtures, and interactions between the HPMC and EC dispersion.

Hypromellose as a Pore Former in Aqueous Ethylcellulose Dispersion: Stability and Film Properties
This poster reprint investigates the effect of HPMC as a pore-former on: stability of aqueous EC dispersion (Surelease®); quality of the free films prepared from these mixtures, and interactions between the HPMC and EC dispersion.

Investigation of Ethylcellulose in the Preparation of Theophylline Extended Release Inert Matrix Tablets
This research illustrates the influence of EC particle size and molecular weight on drug release from inert matrices containing a sparingly water soluble drug. The influence of varying the polymer concentration, filler choice and compression force on drug release was also evaluated.

Investigation of Venlafaxine HCl Release from Extruded and Spheronized Beads Coated with Ethylcellulose using Organic or Aqueous Coating Systems
The objective of this study was to investigate the overall performance of an extruded and spheronized formulation containing venlafaxine HCl, a highly water soluble drug (572 mg/mL)(3), coated with ethylcellulose from organic or aqueous systems.

Investigation of a Directly Compressible Hypromellose Matrix Formulation for a Low Dose, Practically Insoluble Drug
This poster reprint investigates the formulation of an extended release, direct compression Indapamide (1.5 mg) matrix tablet using METHOCEL™.

Investigation of the Relationship between Formulation Variables and Drug Release in Aqueous Ethylcellulose Coating
This poster reprint summarizes the effect of pore former on the drug release of various actives from drug layered beads coated with Surelease®, aqueous ethylcellulose dispersion.

Investigation of the Relationship between Formulation Variables and Drug Release in Aqueous Ethylcellulose Coating
This poster reprint summarizes the effect of pore former on the drug release of various actives from drug layered beads coated with Surelease®, aqueous ethylcellulose dispersion.

Predictability of Drug Release from Multiparticulate Systems Coated with an Aqueous Ethylcellulose Dispersion
This poster reprint examines drug release from drug layered beads varying in substrate size, and Surelease® coating level.

The Effect of Hypromellose as a Pore-Former on Drug Release from Aqueous Ethylcellulose Film-Coated Dipyridamole-Loaded Non-Pareil Beads
This poster reprint investigates the influence of pore-formers on the release of a poorly water-soluble drug, dipyridamole, from non-pareil beads coated with an aqueous ethylcellulose dispersion (Surelease® NG E-7-19050).

The Influence of Hydrophilic Pore Formers on Dipyridamole Release from Aqueous Ethylcellulose Film-Coated Pellets
This poster reprint studies the effect of incorporating water-soluble polyvinyl alcohol (PVA) and polyethylene glycol (PEG) as a pore former into Surelease® films, and how they influence dipryridamole release from the pellets.

The Influence of Post Coating Thermal Treatment on Film Properties and Drug Release from Ethylcellulose Barrier Membrane Coating Systems
The results of this study demonstrate that post coating treatment can affect both physico-mechanical properties of EC films and drug release from EC-coated multi-particulates.

Application of a Modeling System in the Formulation of Extended Release Hydrophilic Matrices
This article reprint describes a predictive formulation service that provides pharmaceutical scientists with a starting formula for hydrophilic matrix tablets.

The Influence of Excipients on Drug Release from Hydroxypropyl Methylcellulose Matrices
Published article reprint that summarizes the influence of various excipient fillers on the drug release from METHOCEL™ matrices.